Police are appealing for information following a three-vehicle collision on the A159 at Scotter on Saturday, April 20.
The collision involved a white Citroen Berlingo, a black Ford Kuga and a grey Vauxhall Insignia.
The driver of the Berlingo, a man in his 40s, was pronounced dead at the scene.
The passenger in the Berlingo, a male teenager, was taken to hospital in Scunthorpe with injuries not thought to be life-threatening.
The driver of the Insignia suffered injuries which were also not thought to be life-threatening, and was taken to hospital in Hull.
Anyone who witnessed the collision, at around 1.45pm, or has dashcam footage, should call 101 quoting Incident 195 of April 20.